The Ingredients That Make CholesLo™ Work
Here are all the synergistic ingredients found in CholesLo™ - each ingredient explaining exactly HOW and WHY it works on the human body. Yes, this information is extensive, but we believe each customer has the right to know exactly what they are putting in their bodies, why it works, and most importantly, how safe the products are - both for short and long-term usage.
Please remember that this product is patent pending and contains clinically proven ingredients in multiple University tested double-blind placebo-controlled trials.
Sytrinol is the newest addition to the CholesLo® formula. Sytrinol is an amazing compound RARELY found in other cholesterol reduction formulas because of the cost.
Sytrinol is derived from natural citrus and palm fruit extracts, combines citrus polymethoxylated flavones (PMFs), palm tocotrienols and other proprietary constituents. This combination results in a synergistic effect for maintaining cholesterol levels in the normal range, including total cholesterol, LDL cholesterol, and triglyceride levels, as demonstrated by a long-term, three phase clinical trial.
Sytrinol has also been shown to maintain normal levels of high density lipoproteins (HDL), the beneficial cholesterol. Additionally, Sytrinol is a powerful antioxidant with numerous heart health benefits and also plays a significant role in reducing cellular irritation.
Sytrinol's Proven Benefits
Sytrinol is the result of over 12 years of research focusing on the relationship between polymethoxylated flavonoids, tocotrienols, and cardiovascular health. Sytrinol's benefits have been demonstrated in multiple clinical studies.
The results of the clinical studies were all similar in their effect, with a reduction of total cholesterol up to 30%, LDL cholesterol up to 27%, and total triglycerides up to 34% in twelve weeks compared to the placebo group. Additionally, the LDL/HDL ratio was significantly reduced in all clinical studies up to 30%.
Also known as CoQ10 and ubiquitone, is a naturally occurring enzyme that is found in every cell in the body. Without CoQ10 NO cell in the body remains alive. The risks of interfering with the production of CoQ10 are unarguable.
CoQ10’s most critical role is to protect and create energy within the cells of the heart and skeletal muscles. The heart has the greatest requirement and highest concentrations of CoQ10 than any other tissue in the body. Reduced levels of CoQ10 can be dangerous to the heart and are a potential factor in heart disease (and prevention).Also known as CoQ10 and ubiquitone, is a naturally occurring enzyme that is found in every cell in the body. Without CoQ10 NO cell in the body remains alive. The risks of interfering with the production of CoQ10 are unarguable.
CoQ10’s most critical role is to protect and create energy within the cells of the heart and skeletal muscles. The heart has the greatest requirement and highest concentrations of CoQ10 than any other tissue in the body. Reduced levels of CoQ10 can be dangerous to the heart and are a potential factor in heart disease (and prevention).
Co-Q10 Can Reverse Heart Disease
Many studies have shown that CoQ1O is necessary for a healthy heart and it can reverse heart disease. Every muscle in the body needs CoQ10 to produce energy, and the heart muscle, having the greatest energy requirement, has the greatest concentration of this nutrient.
However, our natural production of CoQ10 peaks in our 20s and declines thereafter. With the main food sources of CoQ10 being organ meats, not usually a part of today's diets, we are prone to a deficiency, especially from middle age onward.
Statin Drugs Deplete Co-Q10v
Most doctors neglect to tell you that taking statin cholesterol reduction drugs, such as Lipitor, Crestor and Zocor - deplete CoQ10 levels TREMENDOUSLY! The irony is that even though these drugs are created to help heart disease - they actually MAKE IT WORSE!
This is why CholesLo® is doctor endorsed to be used as a safe REPLACEMENT or alternative for statin drugs or used even in conjunction with them. Therefore, you can use LESS of these deadly drugs and rely more on safer, all natural alternatives - such as the ingredients found in CholesLo®.
Policosanol is a natural supplement derived from sugar cane. The main ingredient is octacosanol. Octacosanol is an alcohol found in the waxy film that plants have over their leaves and fruit.
Policosanol has been shown to normalize cholesterol as well or better than cholesterol-lowering drugs, without side effects such as liver dysfunction and muscle atrophy (Mas et al. 1999). Efficacy and safety have been proven in numerous clinical trials, and it has been used by millions of people in other countries. Policosanol lowers harmful LDL-cholesterol and raises protective HDL-cholesterol. HDL-cholesterol removes plaque from arterial walls.
In the last few years, clinical research has also discovered other effects, including reducing symptoms of an enlarged prostate, improving the control of blood sugar among people with diabetes, and reducing inflammation among patients with autoimmune diseases such as rheumatoid arthritis and lupus.
IMPORTANT NOTE: If you choose not to use our clinically proven CholesLo™ product (for whatever reason) and go with another company's product that contains Policosanol, make sure it contains specific "octacosanol" form and NOT the cheaper form of "beta-sistosterol", which is better suited for prostate inflammation and NOT cholesterol reduction.
Deoderized Garlic Extract (1.3% alliin)
A study published in the Journal of Nutrition Research (1987, 7:139-49) showed that a garlic extract caused a 12 to 31% reduction in cholesterol levels in the majority of test subjects after 6 months. The study showed that 73% of the subjects given the garlic (with a specific extract 1.3% alliin) experienced a greater than 10% reduction in cholesterol, compared with only 17% of the subjects in the placebo group showing the same improvement.
Garlic supplementation is especially important if you have high LDL cholesterol levels because LDL cholesterol oxidation causes atherosclerosis, and garlic specifically inhibits LDL oxidation. And garlic helps protect the arterial lining against oxidation. Most importantly, garlic prevents abnormal platelet aggregation (clotting) via several different mechanisms. The formation of arterial blood clots is the primary cause of most heart attacks and strokes.
IMPORTANT NOTE: Investigators reported in a study published in the American Journal of Clinical Nutrition (1996, 64:866-70) that the daily administration of 7.2 grams (that's over 7000 mgs) of Kyolic brand garlic powder (NOT the extracted 1.3% alliin found in CholesLo™) for 6 months produced a modest reduction (of between 2.1 and 3%) in total cholesterol, compared with the placebo group. Basically, it didn't do much.
The heart-healthy benefits of garlic include protecting the endothelial lining of the arterial system against oxidative damage. Fatty plaque is comprised of many substances, including cholesterol. When plaque accumulates in the coronary arteries, the condition can lead to heart attack. In a study of 280 adults, German researchers reported that participants who took 900 mg of garlic powder a day had up to 18% less plaque in their arteries than those who took a placebo, or "dummy," powder.
Male study participants who took a placebo had a 5.5% increase in plaque volume, while those who took the garlic powder experienced just a 1.1% increase in plaque buildup during the 4-year study period. By comparison, women who took the garlic showed a 4.6% decrease in plaque volume, while those who took the placebo powder had a 5.3% increase. Garlic may affect plaque buildup by reducing blood platelet stickiness (aggregation) and specifically preventing the oxidation of LDL cholesterol onto the lining of the arteries. Platelet aggregation helps plaque cling to the arteries.
An April 1998 study reported on the effect of garlic on blood lipids, blood sugar fibrogen, and fibrinogenic activity of 30 patients who received 4 grams of garlic daily for 3 months. The patients were monitored at 1.5 and 3 months when it was determined that garlic had "significantly reduced total serum cholesterol and triglycerides, and significantly increased HDL cholesterol." With regard to fibrinogenic activity, it was determined that the garlic inhibited platelet aggregation (Prostagland. Leuk. Essent. Fatty Acids, April 1998, 58:257-63).
An earlier study in June 1994, the University of Massachusetts Medical School published a report that found that those U.S. adults who consumed one-half to one clove of garlic each day showed cholesterol levels that were reduced by 9% (JAMA, June 1, 1994, 271:1660-61). A survey of 7 out of 8 studies on garlic showed that dosages of between 600 to 900 mg of garlic powder (Allium sativum L.) produced a 5 to 20% reduction in cholesterol and triglycerides. (Fortschr. Med. (Germany) 1990, 108:49-54). Other studies have shown that much higher doses of garlic were required for cholesterol reduction.
Human patients fed a daily dose of garlic (Extract 1.3% alliin) over a 10-month study showed that "adhesion to fibrinogen was reduced by 30%-compared to placebo . . . and that . . . the beneficial effect of garlic preparations on lipids and blood pressure extends also to platelet function" (Journal of Cardiovascular Pharmacology [United States], 1998, 31:904-8).
IMPORTANT NOTE: As you have read from the above research material, the most important factor is that the EXTRACTED 1.3% alliin form works and the powdered form barely works and you would need THOUSANDS of milligrams daily with the non-extracted form (a waste of money). Also know that garlic will make your mouth and entire body smell badly, so it's best to select a "deodorized" version, like the one found in our CholesLo™ product - so you won't smell bad.
Guggulsterones (10% Pure Extract; E and Z)
This powerful ancient remedy has been re-discovered by Western culture. Gugulipid is made from the resin of the commiphora mukul tree of north central India. Gugulipid (gugulesterones) has been used for thousands of years to alleviate problems associated with obesity, acne, viral infections, and other ailments.
In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed an 11% decrease in total serum cholesterol, a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within 3 to 4 weeks. Patients with elevated cholesterol levels showed much greater improvement than normal patients.
The study quoted a second trial (included in the article noted above) where 205 patients receiving gugulipid at a dose rate of 25 mg at 10% extract E and Z forms, administered 3 times daily showed a 70% to 80% reduction of serum cholesterol, whereas no response was found in the placebo group (Journal of Associated Physicians-India, 1989, 37:328).
A placebo-controlled trial of 40 patients with high blood-fat levels showed a serum cholesterol reduction of 21.75%, with triglycerides being reduced by 27.1% in only 3 weeks, and after continuing the study for 16 weeks it was learned that HDL cholesterol was increased by 35.8% (Journal of Associated Physicians-India, 1989, 37:328).
IMPORTANT NOTE: "Guggul" is an amazing compound because it has so many health benefits - two of which are very important to most people - WEIGHT LOSS and CHOLESTEROL REDUCTION. It exerts most of its benefits through the thyroid gland (by normalizing and optimizing production). As stated already, powdered forms do NOT work. It has to be 10% Pure Extract; both E and Z forms. A minimum of 50 mgs daily is needed (75 mgs is what is used in CholesLo™).
Artichoke Leaf Extract (15% Chlorogenic Acid, 5% Cynarin)
The discovery that artichoke leaf extract reduces elevated cholesterol levels opens up exciting perspectives in the prevention and treatment of arteriosclerosis and coronary heart disease.
It was as early as the 1930s that scientists first discovered that artichoke extract had a favorable effect on atherosclerotic plaques in the arteries (Tixier, 1939). Later animal studies, in which rats were fed a high-fat diet, also showed that artichoke extract prevented a rise in serum cholesterol levels and the manifestation of atherosclerotic plaque (Samochowiec, 1959 and 1962).
In addition to findings in animal experiments (Samochowiec et al., 1971; Frohlich and Ziegler, 1973; Wojcicki 1976; Lietti 1977 and 1978), a study by Fintelmann in 1996 of 553 outpatients demonstrated a significant effect of the extract on fat (lipid) metabolism. The researchers found a significant decline in both the cholesterol and triglyceride levels in the blood, which confirmed a discovery made as early as the 1930s.
In another double-blind, placebo-controlled study of 143 people with high cholesterol, artichoke leaf extract using 5% Cynarin significantly improved cholesterol readings9. Total cholesterol fell by 18.5% as compared to 2.6% in the placebo group; LDL cholesterol by 23% vs. 6%; and LDL-to-HDL ratios by 20% vs. 7%.
Yet, without the extracted form of (15% Chlorogenic Acid, 5% Cynarin) and with the use of "artichoke leaf powder", there was NO improvement!
Red Rice Yeast (10:1 Lovastatin Extract - citrinin removed)
This is a very powerful ingredient - ONLY when used in the correct form and quantity - so please read on.
The red yeast (Monascus Purpureus) fermented on rice has been used in China for its health-promoting effects for over 2000 years. This yeast is the source of a group of compounds known as monacolins that can lower cholesterol levels by blocking a key enzyme in the liver.
In fact, the cholesterol lowering prescription drug Mevacor®, is the trade name for the compound lovastatin, also known as monacolin K, one of the key monacolins in red yeast rice extract. Hence, BOTH the drug Mevacor® and the natural ingredient of red yeast rice extract contain the SAME EXACT CHOLESTEROL REDUCING COMPOUND CALLED "lovastatin".
This is why red yeast rice extract is so powerful and works so well! The same reason that the pharmaceutical giant Merck tried to NOT allow any sales of this natural compound, and actually DID WIN IN COURT, but then the judgment was reversed.
This compound - lovastatin - is similar to other "statin" drugs such as Lipitor® (atorvastatin), Crestor® (rosuvastatin), and Zocor® (simvastatin).
Hence, red yeast rice extract works so well as a natural compound, that drug companies have tried to duplicate other man-made ingredients to do the same job. One important note though ... lovastatin (which is the same as red yeast rice extract and the drug Mevacor), can become very toxic to the body and liver.
The key is to have the toxic by-product called "citrinin" REMOVED from the fermentation process - to which CholesLo™ has done and this is why the red yeast rice extract found in our product is VERY SAFE!
IMPORTANT NOTE & SUMMARY: The above had a lot of important information on how this amazing natural compound works and has been used safely for over 2000 years in China. But basically, "red yeast rice extract" contains a compound called "lovastatin", which works so well at reducing cholesterol, that the pharmaceutical company Merck designed a drug called Mevacor® to have the SAME EXACT INGREDIENT. BUT, you have to make sure that the toxic fermentation by-product called "citrinin" has been removed - and this HAS been done with CholesLo™!
Plant sterols and plant stanols are collectively known as phytosterols. Plant sterols are plant compounds with chemical structures similar to that of cholesterol. Especially high sterol levels are found in rice bran, wheat germ, corn oils, and soybeans.
Interestingly, phytosterols so closely resemble cholesterol that they can actually block food-based cholesterol from being absorbed into the bloodstream. The result is that both phytosterols and dietary cholesterol end up excreted in waste matter.
Because of their ability to block dietary cholesterol absorption, phytosterols can help lower your cholesterol levels. In the last few years, clinical research has also discovered other effects, including reducing symptoms of an enlarged prostate, improving the control of blood sugar among people with diabetes, and reducing inflammation among patients with autoimmune diseases such as rheumatoid arthritis and lupus.
Studies have shown that daily phytosterols can lower these cholesterol measurements by an average of 10% to 14%. Because of these strong findings, the National Cholesterol Education Panel issued a new recommendation in 2001 that plant stanols and sterols be added to cholesterol-lowering regimens, along with the more traditional cholesterol-fighting tools, such as regular exercise, weight loss, and a low-fat diet.
Liver Cleansing Formula (Milk Thistle, NAC, Alpha Lipoic Acid & Turmeric)
Most of the body's supply of cholesterol (approximately 80%) is made in the liver. This process is rigorously controlled by biochemical feedback mechanisms. The amount of cholesterol produced by the liver is controlled by the enzyme HMG-CoA reductase (by the way, the above ingredient Red Rice Yeast extract works mainly by inhibiting this enzyme).
As you can see, the liver is the "power house" in the body for many functions, but especially cholesterol. Many people have unhealthy livers to do lack of hydration because they don't drink enough water, to use of too many prescription drugs (or any drug for that matter), alcohol consumption and a poor diet.
So, if your liver is weak and tired from always trying to clean out and filter all the junk you are putting in your body every day, it won't have enough energy to regulate your cholesterol levels and therefore, cholesterol rises.
We've added THREE very potent liver detoxers, to help strengthen your liver and boost your immune system - Milk Thistle (80% Extract), NAC (N-Acetyl L-Cysteine), Alpha Lipoic Acid (ALA) and Turmeric (95% curcuminoids Extract). All help to lower cholesterol and triglycerides, but through an "indirect" route and work SYNERGISTICALLY with the rest of the ingredients found in CholesLo™.
Turmeric - Kill TWO Birds With ONE Stone ...
But turmeric has additional benefits to liver cleansing in that it also lowers cholesterol DIRECTLY on its own.
Animals fed small doses of Turmeric (95% curcuminoids Extract) had their cholesterol levels drop by one half (50%) over those that did not receive Turmeric. It reduces cholesterol by interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids, and increasing the excretion of bile acids, according to the International Journal of Vitamin Nutritional Research (1991, 61:364-69).
The 1992 Indian Journal of Physiology reported that ten human volunteers taking Turmeric showed a 29% increase in beneficial HDL cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33%.
In January of 1997, the Journal of Molecular Cell Biochemistry reported curcumin has demonstrated, in vivo, the ability to decrease total cholesterol and LDL cholesterol levels in serum and to increase the beneficial HDL cholesterol. "Blood cholesterol was lowered significantly by dietary curcumin in these diabetic animals. Significant decrease in blood triglyceride and phospholipids was also brought about by dietary Turmeric in diabetic rats."
The research has continued and curcumin's ability to lower blood cholesterol levels was reported in the April 1998 issue of Molecular Cell Biochemistry, and again, later that year, researchers in Biofactors (1998, 8:1-2, 51-57) reported that "Turmeric extract may be protective in preventing lipoperoxidation of subcellular membranes."
Turmeric also provides an additional benefit by potentially reducing the risk of cardiovascular-related disease as it inhibits platelet aggregation and significantly decreases the level of lipid (LDL) peroxidation. "Observation of Turmeric's mechanism of action shows that it blocks the formation of thromboxane A2, a promoter of platelet aggregation, thereby inhibiting abnormal blood clot formation. Turmeric also increases a prostacyclin, a natural inhibitor of platelet aggregation" (Arzneim. Forsch., 1986, 36:715-17)."
IMPORTANT NOTE: Turmeric and/or Curcumin ROOT does not work. It has to be the EXTRACTED form and the higher the better. In CholesLo™, we use 95% curcuminoids Extract.
Homocysteine Reducing Formula
Researchers now believe that testing homocysteine levels is over 40% more accurate at predicting heart disease, than checking cholesterol. So, just because you lower your cholesterol (diet, drugs, etc.), does NOT mean you're "safe" when it comes to heart disease, stokes or heart attacks.
Make sure you ALSO check your Homocysteine levels and keep them fairly low, in the range of 5-15 micromoles per liter of blood (best if it's less than 10).
How It Works & Why
About 50% of American adults have elevated blood cholesterol levels, a key risk factor for heart disease according to the National Heart, Lung, and Blood Institute. But are you aware that half of all heart attacks happen to people with normal blood cholesterol levels?
That's because your blood cholesterol provides your total cholesterol, including high-density lipoproteins (HDL) and low-density lipoproteins (LDL) but not some other important numbers, like your homocysteine level and C reactive protein.
What Is Homocysteine?
Homocysteine, an amino acid in the blood, is associated with an increased risk of heart attack and stroke. Some medical experts predict that homocysteine levels will prove to be as important as cholesterol in predicting heart health. In fact, they expect measuring homocysteine levels will become a part of regular cardiac risk assessments.
What Causes Elevated Homocysteine?
Studies have shown that high levels of homocysteine are caused by a lack of nutrients in the diet, particularly the B group of vitamins. Without these essential vitamins your body is unable to produce the enzymes necessary to remove homocysteine efficiently from your blood.
Homocysteine will cause damage to your arteries when present in high concentrations - hence the link between homocysteine and heart disease.
How Can You Treat Homocysteine?
A lack of B Vitamins leads to elevated homocysteine levels, which is why high homocysteine and vegetarian diets are directly related. Fortunately the situation is easily treatable.
In the late 60's Dr. Kilmer McCully determined through extensive research that taking adequate amounts of folic acid (vitamin B9), along with vitamins B6 and B12 your levels of homocysteine will normalize.
Numerous studies since have proven Dr. McCully's work to be 100% accurate and the correct total daily dosage for these B vitamins should be around:B9 - Folic Acid: 200-600 mcgs
B6: 20-60 mgs
B12: 100-300 mcgs
These are TOTAL daily dosages and this is the EXACT ratio we've used in CholesLo. With the minimum of 2 pills daily, to a maximum of 6 pills - you will fall in the EXACT clinically proven range to effectively reduce Homocysteine Levels!
With powerful ingredients like these, you can see why you will lower your cholesterol by at least 15% in the next 12 weeks or I will pay you $100 cash. That’s my guarantee!